Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Giardia duodenalis is a major gastrointestinal parasite of humans and animals across the
globe. It is also of interest from an evolutionary perspective as it possesses many features …

Protozoan parasites of the Leishmania donovani complex–L. donovani and L. infantum–
cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome …

Reduced susceptibility to infectious disease can increase the frequency of otherwise
deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) …

Sex strongly impacts genome evolution via recombination and segregation. In the absence
of these processes, haplotypes within lineages of diploid organisms are predicted to …

Human African trypanosomiasis (HAT) is responsible for around 3000 reported cases each
year. Treatments for HAT are expensive and problematic to administer, and available drugs …

Genetic exchange enables parasites to rapidly transform disease phenotypes and exploit
new host populations. Trypanosoma cruzi, the parasitic agent of Chagas disease and a …

Sexual reproduction is almost ubiquitous among extant eukaryotes. As most asexual
lineages are short-lived, abandoning sex is commonly regarded as an evolutionary dead …

Evolution without sex is predicted to impact genomes in numerous ways. Case studies of
individual parthenogenetic animals have reported peculiar genomic features that were …

African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …