Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …

• Introduction• Mitochondria and cell death• Mitochondrial outer membrane permeabilization
(MOMP): point of no return‐MOMP by BCL‐2 family proteins‐MOMP by permeability …

The results of a comprehensive in vivo study of a novel tumor-targeting modality are
reported. The technique utilized in this study is based on the encapsulation of the …

Cardiac surgery and some noncardiac procedures are associated with a significant risk of
perioperative cardiac morbid events. Experimental data indicate that clinical concentrations …

Cardiac preconditioning represents the most potent and consistently reproducible method of
rescuing heart tissue from undergoing irreversible ischaemic damage. Major milestones …

Reactive oxygen species (ROS) are central to cardiac ischemic and reperfusion injury. They
contribute to myocardial stunning, infarction and apoptosis, and possibly to the genesis of …

Reperfusion therapy is the indispensable treatment of acute myocardial infarction (AMI) and
must be applied as soon as possible to attenuate the ischemic insult. However, reperfusion …

The mitochondrion is the most important organelle in determining continued cell survival
and cell death. Mitochondrial dysfunction leads to many human maladies, including …

The mechanisms of volatile anesthetic action remain among the most perplexing mysteries
of medicine. Across phylogeny, volatile anesthetics selectively inhibit mitochondrial complex …

Mitochondrial disease, once thought to be a rare clinical entity, is now recognized as an
important cause of a wide range of neurologic, cardiac, muscle, and endocrine disorders …