Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA
damage and other effects important in cancer transformation. Dietary vitamin C from natural …

Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …

Severe systemic inflammatory response to infection results in severe sepsis and septic
shock, which are the leading causes of death in critically ill patients. Septic shock is …

Vitamin C is an essential dietary requirement for humans. In addition to its known role as an
antioxidant, vitamin C is a cofactor for Fe 2+-and α-ketoglutarate-dependent dioxygenases …

Whether vitamin C (ascorbate) has a role to play as an anti-cancer agent has been debated
for decades. Ascorbate has been used by cancer patients in an unregulated environment …

The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and
recent epidemiological evidence has indicated an association between suboptimal vitamin …

DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …

Background Circulating vitamin C concentrations have been associated with several
cancers in observational studies, but little is known about the causal direction of the …