Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

The term type III diabetes (T3DM) has been proposed for Alzheimer's disease (AD) due to
the shared molecular and cellular features between type 2 diabetes (T2DM) and insulin …

The medium-chain fatty acids octanoic acid (C8) and decanoic acid (C10) are gaining
attention as beneficial brain fuels in several neurological disorders. The protective effects of …

Brain computer interfaces (BCIs), including penetrating microelectrode arrays, enable both
recording and stimulation of neural cells. However, device implantation inevitably causes …

In multiple sclerosis (MS), astrocytes respond to the inflammatory stimulation with an early
robust process of morphological, transcriptional, biochemical, and functional remodeling …

Alzheimer's disease (AD) is a neurodegenerative disease in which oxidative stress and
neuroinflammation were demonstrated to be associated with neuronal loss and cognitive …

We previously showed the anti-inflammatory effects of kynurenic acid (KYNA) and its brain-
penetrable analog N-(2-(dimethylamino) ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2 …

Sleep plays an essential role in all studied animals with a nervous system. However, sleep
deprivation leads to various pathological changes and neurobehavioral problems …

In recent years, the need for sophisticated human in vitro models for integrative biology has
motivated the development of organ-on-a-chip platforms. Organ-on-a-chip devices are …

Abstract Adenosine A 2A-receptors (A 2A R) and dopamine D 2-receptors (D 2 R) are known
to work together in a synergistic manner. Inhibiting A 2A Rs by genetic or pharmacological …