Epidermal growth factor receptor (EGFR) was one of the first oncogenes identified in
glioblastoma (GBM) and remains one of the most attractive therapeutic targets. Genomic …

Abstract 1p19q co-deletion is a chromosomal alteration associated with primary brain
tumours of oligodendroglial histology. It is an established predictive and prognostic …

Low-grade gliomas (GII) inescapably progress to high-grade gliomas (GIII). The duration of
this transition is highly variable between patients and reliable predictive markers do not …

Oligodendroglioma represents a distinctive neoplasm in adults but similar neoplasms occur
rarely in children. We studied 20 cases of pediatric oligodendroglioma by SNP array …

Background Complete deletion of both the short arm of chromosome 1 (1p) and the long arm
of chromosome 19 (19q), known as 1p/19q codeletion, is a mutation that can occur in …

Whole-genome copy number analysis platforms, such as array comparative genomic
hybridization (aCGH) and single nucleotide polymorphism (SNP) arrays, are transformative …

Deletion or loss of heterozygosity (LOH) in chromosomes 1p and 19q in oligodendrogliomas
(ODGs) have diagnostic, prognostic, and therapeutic implications. Current clinical assays …

Progress in understanding the molecular biology of neoplasms has been driven by
remarkable improvements in molecular biology techniques, creating a rapidly moving field in …

A collection of intracranial astrocytomas of different malignancy grades was analyzed for
copy number aberrations (CNA) in order to identify regions that are driving cancer …

Bladder carcinogenesis is believed to follow two alternative pathways driven by the loss of
chromosome 9 and the gain of chromosome 7, albeit other nonrandom copy number …