Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Bone marrow-derived mesenchymal stem cells (BMDMSCs) appear to be important in repair
of the chronic lung injury caused by bleomycin in mice. To determine effects of these …

Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein,
early pro-inflammatory phases are characterized and regulated by prostanoids and …

Prostacyclin, or PGI2, is an end product derived from the sequential metabolism of
arachidonic acid via cyclooxygenase and PGI synthase (PGIS). The receptor for PGI2, IP …

Cardiovascular diseases are the leading cause of global deaths, and many risk factors
contribute to their pathogenesis. In this context, prostanoids, which derive from arachidonic …

Prostaglandins are synthesized through the metabolism of arachidonic acid via the
cyclooxygenase pathway. There are five primary prostaglandins, PGD 2, PGE 2, PGF 2, PGI …

Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane
phospholipids by phospholipase A2 to ω-3 and ω-6 C20 fatty acids that next are converted …

Rationale: Group 2 innate lymphoid cells (ILC2s) robustly produce IL-5 and IL-13, cytokines
central to the asthma phenotype; however, the effect of prostaglandin (PG) I2 on ILC2 …

Prostaglandins (PGs) are products of the COX pathway of arachidonic acid metabolism.
There are five primary PGs, PGD2, PGE2, PGF2, PGI2 and thromboxane A2, all of which …