Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …

Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

Lung cancer continues to be a malignant tumor with high mortality. Two obstacles interfere
with curative therapy of lung cancer:(i) poor diagnosis at the early stages, as symptoms are …

Cancer cells and immune cells all undergo remarkably metabolic reprogramming during the
oncogenesis and tumor immunogenic killing processes. The increased dependency on …

Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where
it performs several functions. In normal cells, citrate sustains protein acetylation, lipid …

Paclitaxel, a natural anticancer drug, is widely recognized and extensively utilized in the
treatment of breast cancer (BC). However, it may lead to certain side effects or drug …

Simple Summary The reprogramming of tumor cell metabolism is an important char acteristic
of cancer, which provides the energy and biomacromolecules in tumor development …

As a key component of the COP9 signalosome complex, which participates in a variety of
physiological processes, COPS3 is intimately related to multiple cancers. It promotes cell …

Background Zinc finger protein 687 (ZNF687) has previously been discovered as a potential
oncogene in individuals with giant cell tumors of the bone, acute myeloid leukemia, and …