The antitumour activity of endogenous or adoptively transferred tumour-specific T cells is
highly dependent on their differentiation status. It is now apparent that less differentiated T …

T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …

Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have shown remarkable
activity in B cell acute lymphoblastic leukemia (B-ALL). The major cause of treatment failure …

BACKGROUND. Chimeric antigen receptor (CAR) T cells can induce remission in highly
refractory leukemia and lymphoma subjects, yet the parameters for achieving sustained …

The β-haemoglobinopathies, such as sickle cell disease and β-thalassaemia, are caused by
mutations in the β-globin (HBB) gene and affect millions of people worldwide. Ex vivo gene …

The success of chimeric antigen receptor (CAR)–mediated immunotherapy in acute
lymphoblastic leukemia (ALL) highlights the potential of T-cell therapies with directed …

Low-affinity CD19 chimeric antigen receptor (CAR) T cells display enhanced expansion and
persistence, enabling fate tracking through integration site analysis. Here we show that …

Upon stimulation with their cognate antigen, naive T cells undergo proliferation and
differentiation into effector cells, followed by apoptosis or survival as precursors of long‐lived …

Adoptive transfer of primary (unmodified) or genetically engineered antigen-specific T cells
has demonstrated astonishing clinical results in the treatment of infections and some …

The use of posttransplant cyclophosphamide (PT-Cy) as graft-versus-host disease (GVHD)
prophylaxis has revolutionized haploidentical hematopoietic stem cell transplantation …