Monocyte and macrophage heterogeneity
S Gordon, PR Taylor - Nature reviews immunology, 2005 - nature.com
Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result
of the specialization of tissue macrophages in particular microenvironments. Circulating …
of the specialization of tissue macrophages in particular microenvironments. Circulating …
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
T Suda, N Takahashi, N Udagawa, E Jimi… - Endocrine …, 1999 - academic.oup.com
OSTEOCLASTS, which are present only in bone, are multinucleated giant cells with the
capacity to resorb mineralized tissues. During the past decade, several new approaches …
capacity to resorb mineralized tissues. During the past decade, several new approaches …
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
YY Kong, H Yoshida, I Sarosi, HL Tan, E Timms… - Nature, 1999 - nature.com
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation …
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation …
Bone marrow, cytokines, and bone remodeling—emerging insights into the pathophysiology of osteoporosis
SC Manolagas, RL Jilka - New England journal of medicine, 1995 - Mass Medical Soc
Bone is remodeled continuously during adulthood through the resorption of old bone by
osteoclasts and the subsequent formation of new bone by osteoblasts. These two closely …
osteoclasts and the subsequent formation of new bone by osteoblasts. These two closely …
Increased osteoclast development after estrogen loss: mediation by interleukin-6
RL Jilka, G Hangoc, G Girasole, G Passeri… - Science, 1992 - science.org
Osteoclasts, the cells that resorb bone, develop from hematopoietic precursors of the bone
marrow under the control of factors produced in their microenvironment. The cytokine …
marrow under the control of factors produced in their microenvironment. The cytokine …
[HTML][HTML] Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) …
F Arai, T Miyamoto, O Ohneda, T Inada… - The Journal of …, 1999 - ncbi.nlm.nih.gov
Osteoclasts are terminally differentiated cells derived from hematopoietic stem cells.
However, how their precursor cells diverge from macrophagic lineages is not known. We …
However, how their precursor cells diverge from macrophagic lineages is not known. We …
Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis.
R Pacifici - Journal of bone and mineral research: the official …, 1996 - europepmc.org
In summary, available data demonstrate that IL-1 and TNF are the causative agents
underlying the bone loss induced by estrogen deficiency. Indeed, these factors are …
underlying the bone loss induced by estrogen deficiency. Indeed, these factors are …
Osteoimmunology: interactions of the bone and immune system
J Lorenzo, M Horowitz, Y Choi - Endocrine reviews, 2008 - academic.oup.com
Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …
skeleton and the body's response to invading pathogens. It has now become clear that these …
Modulation of osteoclast differentiation
T Suda, N Takahashi, TJ Martin - Endocrine reviews, 1992 - academic.oup.com
I. Introduction B ONE is a complex tissue in which resorption and formation continue
throughout life. This process is called bone remodeling. Osteotropic hormones such as 1α …
throughout life. This process is called bone remodeling. Osteotropic hormones such as 1α …
Sex steroids and bone
JE Compston - Physiological reviews, 2001 - journals.physiology.org
Sex steroids are essential for skeletal development and the maintenance of bone health
throughout adult life, and estrogen deficiency at menopause is a major pathogenetic factor …
throughout adult life, and estrogen deficiency at menopause is a major pathogenetic factor …