Primary cilia as dynamic and diverse signalling hubs in development and disease

P Mill, ST Christensen, LB Pedersen - Nature Reviews Genetics, 2023 - nature.com
Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Zebrafish: an important model for understanding scoliosis

H Xie, M Li, Y Kang, J Zhang, C Zhao - Cellular and Molecular Life …, 2022 - Springer
Scoliosis is a common spinal deformity that considerably affects the physical and
psychological health of patients. Studies have shown that genetic factors play an important …

Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex

JY Wu, SJ Cho, K Descant, PH Li, A Shapson-Coe… - Neuron, 2024 - cell.com
Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …

Modulation of inner junction proteins contributes to axoneme differentiation

Z Chen, M Li, H Zhu, G Ou - Proceedings of the National …, 2023 - National Acad Sciences
Cilia build distinct subdomains with variable axonemal structures to perform diverse
functions in cell motility and signaling. In sensory cilia across species, an axoneme …

A multicellular developmental program in a close animal relative

M Olivetta, C Bhickta, N Chiaruttini, J Burns, O Dudin - Nature, 2024 - nature.com
All animals develop from a single-celled zygote into a complex multicellular organism
through a series of precisely orchestrated processes,. Despite the remarkable conservation …

A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans

J Dobbelaere, TY Su, B Erdi, A Schleiffer… - The EMBO …, 2023 - embopress.org
Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …

Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins

L Li, J Ran - Cell Death & Disease, 2024 - nature.com
Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are
involved in sensory perception, motility, and signaling. Their proper assembly and function …

Cilia as Wnt signaling organelles

C Niehrs, F Da Silva, C Seidl - Trends in Cell Biology, 2024 - cell.com
Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and,
conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are …

Cryo-EM reveals how the mastigoneme assembles and responds to environmental signal changes

Y Wang, J Yang, F Hu, Y Yang, K Huang… - Journal of Cell …, 2023 - rupress.org
Mastigonemes are thread-like structures adorning the flagella of protists. In Chlamydomonas
reinhardtii, filamentous mastigonemes find their roots in the flagella's distal region …

XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis

R Hong, Y Tan, X Tian, Z Huang, J Wang, H Ni… - EMBO …, 2024 - embopress.org
Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the
molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that …