Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …

Convalescent plasma has been used worldwide to treat patients hospitalized with
coronavirus disease 2019 (COVID-19) and prevent disease progression. Despite global …

Importance The evidence for benefit of convalescent plasma for critically ill patients with
COVID-19 is inconclusive. Objective To determine whether convalescent plasma would …

Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19
pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin …

Our understanding of immune responses to SARS-CoV-2 and variants of concern (VOCs)
has been primarily acquired through analysis of Spike-specific IgG responses. However, a …

The efficacy of COVID-19 mRNA vaccines is high, but breakthrough infections still occur. We
compared the SARS-CoV-2 genomes of 76 breakthrough cases after full vaccination with …

A versatile portfolio of diagnostic tests is essential for the containment of the severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic. Besides nucleic acid …

We compared the performance of SARS-CoV-2 neutralising antibody testing between 12
European laboratories involved in convalescent plasma trials. Raw titres differed almost 100 …

Background The antiviral efficacy of remdesivir in COVID-19 hospitalized patients remains
controversial. Objectives To estimate the effect of remdesivir in blocking viral replication …

Purpose Benefit from convalescent plasma therapy for coronavirus disease 2019 (COVID-
19) has been inconsistent in randomized clinical trials (RCTs) involving critically ill patients …