[HTML][HTML] The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Tales of detailed poly (A) tails

AL Nicholson, AE Pasquinelli - Trends in cell biology, 2019 - cell.com
Poly (A) tails are non-templated additions of adenosines at the 3′ ends of most eukaryotic
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …

Nanopore native RNA sequencing of a human poly (A) transcriptome

RE Workman, AD Tang, PS Tang, M Jain, JR Tyson… - Nature …, 2019 - nature.com
High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …

An atlas of plant full-length RNA reveals tissue-specific and monocots–dicots conserved regulation of poly (A) tail length

J Jia, W Lu, B Liu, H Fang, Y Yu, W Mo, H Zhang, X Jin… - Nature Plants, 2022 - nature.com
Poly (A) tail is a hallmark of eukaryotic messenger RNA and its length plays an essential role
in regulating mRNA metabolism. However, a comprehensive resource for plant poly (A) tail …

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes

Y Li, Y Yi, J Lv, X Gao, Y Yu, SS Babu… - Nucleic acids …, 2023 - academic.oup.com
Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …

Measuring the tail: Methods for poly (A) tail profiling

A Brouze, PS Krawczyk… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …

Drought induces epitranscriptome and proteome changes in stem-differentiating xylem of Populus trichocarpa

Y Gao, X Liu, Y Jin, J Wu, S Li, Y Li, B Chen… - Plant …, 2022 - academic.oup.com
Understanding gene expression and regulation requires insights into RNA transcription,
processing, modification, and translation. However, the relationship between the …

[HTML][HTML] Transcription dynamics regulate poly (A) tails and expression of the RNA degradation machinery to balance mRNA levels

B Slobodin, A Bahat, U Sehrawat, S Becker-Herman… - Molecular cell, 2020 - cell.com
Gene expression is regulated by the rates of synthesis and degradation of mRNAs, but how
these processes are coordinated is poorly understood. Here, we show that reduced …

tailfindr: alignment-free poly (A) length measurement for Oxford Nanopore RNA and DNA sequencing

M Krause, AM Niazi, K Labun, YNT Cleuren, FS Müller… - RNA, 2019 - rnajournal.cshlp.org
Polyadenylation at the 3′-end is a major regulator of messenger RNA and its length is
known to affect nuclear export, stability, and translation, among others. Only recently have …

Transcriptome-wide measurement of poly (A) tail length and composition at subnanogram total RNA sensitivity by PAIso-seq

Y Liu, Y Zhang, J Wang, F Lu - Nature Protocols, 2022 - nature.com
Poly (A) tails are added to the 3′ ends of most mRNAs in a non-templated manner and play
essential roles in post-transcriptional regulation, including mRNA export, stability and …