Metabolic regulation of skeletal cell fate and function in physiology and disease

N Van Gastel, G Carmeliet - Nature Metabolism, 2021 - nature.com
The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

[HTML][HTML] Impacts of psychological stress on osteoporosis: clinical implications and treatment interactions

RR Kelly, LT McDonald, NR Jensen, SJ Sidles… - Frontiers in …, 2019 - frontiersin.org
The significant biochemical and physiological effects of psychological stress are beginning
to be recognized as exacerbating common diseases, including osteoporosis. This review …

Multiomics of tissue extracellular vesicles identifies unique modulators of atherosclerosis and calcific aortic valve stenosis

MC Blaser, F Buffolo, A Halu, ME Turner, F Schlotter… - Circulation, 2023 - Am Heart Assoc
BACKGROUND: Fewer than 50% of patients who develop aortic valve calcification have
concomitant atherosclerosis, implying differential pathogenesis. Although circulating …

Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53Lys382 Signaling, Mediating the Onset of Cd-Induced Osteoporosis

D Ran, D Zhou, G Liu, Y Ma, W Ali, R Yu… - Journal of Agricultural …, 2023 - ACS Publications
The imbalance between osteogenesis and osteoclastogenesis is a feature of bone
metabolic disease. Cadmium (Cd) exposure causes human bone loss and osteoporosis …

Biomarkers associated with the pathogenesis of Alzheimer's disease

H Wang, M Sun, W Li, X Liu, M Zhu… - Frontiers in Cellular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …

[HTML][HTML] Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices

C Ruggiero, M Baroni, D Xenos, L Parretti… - Ageing research …, 2024 - Elsevier
Dementia, osteoporosis, and fragility fractures are chronic diseases, often co-existing in
older adults. These conditions pose severe morbidity, long-term disability, and mortality, with …

Osteoporosis and Alzheimer´ s disease (or Alzheimer´ s disease and Osteoporosis)

NE Wanionok, GR Morel, JM Fernández - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) and osteoporosis are two diseases that mainly affect elderly
people, with increases in the occurrence of cases due to a longer life expectancy. Several …

Calcium alleviates fluoride-induced bone damage by inhibiting endoplasmic reticulum stress and mitochondrial dysfunction

J Wang, J Yang, X Cheng, R Xiao, Y Zhao… - Journal of agricultural …, 2019 - ACS Publications
Excessive fluoride mainly causes skeletal lesions. Recently, it has been reported that an
appropriate level of calcium can alleviate fluorosis. However, the appropriate concentration …

Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone

L Chen, L Xiong, L Yao, J Pan, E Arzola, X Zhu… - Alzheimer's research & …, 2023 - Springer
Background Alzheimer's disease (AD) and osteoporosis are two distinct diseases but often
occur in the same patient. Their relationship remains poorly understood. Studies using …

Alzheimer's disease and its associated risk of bone fractures: a narrative review

BN Zhou, Q Zhang, M Li - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Alzheimer's disease (AD) is a neurodegenerative disorder that is the major
cause of dementia in the aged population. Recent researches indicate that patients with AD …