In addition to their bioenergetic intracellular function, several classical metabolites act as
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and
inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of …

Maintaining a constant level of blood Ca 2+ is essential because of calcium's myriad
intracellular and extracellular roles. The CaSR plays key roles in maintaining Ca 2+ o …

Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are
caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic …

Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be
prevented in humans and animals by high calcium intake, suggesting that intestinal calcium …

The extracellular calcium (Ca2+ o)-sensing receptor (CaR) recognizes and responds to
(ie,“senses”) Ca2+ o as its principal physiological ligand. In the present studies, we …

There is evidence from both observational studies and clinical trials that calcium malnutrition
and hypovitaminosis D are predisposing conditions for various common chronic diseases. In …

Context: The inability to accurately localize the parathyroid glands during parathyroidectomy
and thyroidectomy procedures can prevent patients from achieving postoperative …

Phosphorus plays a critical role in diverse biological processes, and, therefore, the
regulation of phosphorus balance and homeostasis are critical to the well being of the …