Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

Gram-positive bacteria are responsible for a broad range of infectious diseases, and the
emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA …

Abstract Classical macrolides containing 14-or 15-membered aglycone lactone rings are
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …

In the search for novel hybrid molecules by fusing two biologically active scaffolds into one
heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin …

The review is devoted to the latest achievements in the design of dual action antibiotics—
heterodimeric (chimeric) structures based on antibacterial agents of different classes …

The emerging antimicrobial resistance (AMR) poses serious threats to the global public
health. Conventional antibiotics have been eclipsed in combating with drug-resistant …

Structure-Activity Relationships and Mechanism of Action of Macrolides Derived from
Erythromycin as Antibacterial Agents Page 1 Send Orders for Reprints to reprints@benthamscience.net …

Gram‐negative pathogens represent a significant global health threat, while the emergency
and widespread of drug resistance make the situation even worse. As “privileged building …

Macrolides are stereospecific macrolactones of high molecular weights. Herein, 600 mostly
semisynthetic macrolides are compared with 50,000 small non-macrolide synthetic …

The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist
of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker …