Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune …

JHC Wong, JYW Ma, AI Jobling, A Brandli… - Frontiers in …, 2022 - frontiersin.org
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the
older population. Classical hallmarks of early and intermediate AMD are accumulation of …

Novel programmed cell death as therapeutic targets in age-related macular degeneration?

M Yang, KF So, WC Lam, ACY Lo - International Journal of Molecular …, 2020 - mdpi.com
Age-related macular degeneration (AMD) is a leading cause of severe visual loss among
the elderly. AMD patients are tormented by progressive central blurring/loss of vision and …

Acute central serous chorioretinopathy: factors influencing episode duration

A Daruich, A Matet, L Marchionno, JD De Azevedo… - Retina, 2017 - journals.lww.com
Purpose: To evaluate the influence of clinical and multimodal imaging parameters on the
duration of acute central serous chorioretinopathy (CSCR) episodes. Methods: Consecutive …

Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity

S Datta, M Cano, G Satyanarayana, T Liu, L Wang… - Autophagy, 2023 - Taylor & Francis
Age-related macular degeneration (AMD), the leading cause of blindness among the
elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) …

Metabolic features of mouse and human retinas: rods versus cones, macula versus periphery, retina versus RPE

B Li, T Zhang, W Liu, Y Wang, R Xu, S Zeng, R Zhang… - Iscience, 2020 - cell.com
Photoreceptors, especially cones, which are enriched in the human macula, have high
energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of …

Deep learning predicts function of live retinal pigment epithelium from quantitative microscopy

NJ Schaub, NA Hotaling, P Manescu… - The Journal of …, 2020 - Am Soc Clin Investig
Increases in the number of cell therapies in the preclinical and clinical phases have
prompted the need for reliable and noninvasive assays to validate transplant function in …

Quantifying retinal pigment epithelium dysmorphia and loss of histologic autofluorescence in age-related macular degeneration

JA Gambril, KR Sloan, TA Swain… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: Lipofuscin and melanolipofuscin organelles in retinal pigment epithelium (RPE)
cells are signal sources for clinical fundus autofluorescence (AF). To elucidate the …

[HTML][HTML] Electrohydrodynamic jet-printed ultrathin polycaprolactone scaffolds mimicking bruch's membrane for retinal pigment epithelial tissue engineering

H Liu, F Wu, R Chen, Y Chen, K Yao, Z Liu… - … Journal of Bioprinting, 2022 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is the leading cause of visual loss and affects
millions of people worldwide. Dysfunction of the retinal pigment epithelium (RPE) is …

Aging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epithelium

JYW Ma, U Greferath, JHC Wong, LJ Fothergill… - Neurobiology of …, 2023 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss and
dysfunction in the retinal pigment epithelium (RPE) with age is known to contribute to …

[HTML][HTML] HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells

DD Chen, X Peng, Y Wang, M Jiang, M Xue… - Aging (albany …, 2021 - ncbi.nlm.nih.gov
The senescence of retinal pigment epithelial (RPE) cells is associated with age-related
macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a …