As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …

Abstract Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated
with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade …

Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …

Response rates to immunotherapy in solid tumors remain low due in part to the elevated
prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …

CD8+ T cells provide host protection against pathogens by differentiating into distinct
effector and memory cell subsets, but how chromatin is site-specifically remodeled during …