Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Biocatalysis has found numerous applications in various fields as an alternative to chemical
catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for …

Enzymes are nature's catalysts that are designed to accelerate specific reactions up to 106
times with high selectivity. 1 The enormous potential of enzymes as catalysts for organic …

Late-stage functionalization of natural products offers an elegant route to create novel
entities in a relevant biological target space. In this context, enzymes capable of …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Modified amino acids are important building blocks in both natural biomolecules and
synthetic small-molecule drugs. Here, we review the roles of iron-and α-ketoglutarate …

Non-heme iron halogenases and hydroxylases activate inert C–H bonds to selectively
catalyze the functionalization of diverse biological products under physiological conditions …

Nonheme iron halogenases are unique enzymes in nature that selectively activate an
aliphatic C–H bond of a substrate to convert it into C–X (X= Cl/Br, but not F/I). It is proposed …

The introduction of a chlorine atom could potentially endow peptide derivatives with notable
bioactivity and applicability. However, despite considerable recent progress in C (sp3)–H …

FeII‐and α‐ketoglutarate‐dependent halogenases and oxygenases can catalyze site‐
selective functionalization of C− H bonds via a variety of C− X bond forming reactions, but …