Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for
monocarboxylate transporters (MCTs), which mediate the absorption and distribution of …

Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive neoplasia lacking
the expression of hormonal receptors and human epidermal growth factor receptor-2 …

Effective control of non-small-cell lung cancer (NSCLC) remains clinically challenging,
especially during advanced stages of the disease. This study developed an adoptive T-cell …

Background Upregulated glucose metabolism is a common feature of tumors. Glucose can
be broken down by either glycolysis or the oxidative pentose phosphate pathway (oxPPP) …

Energy production by cancer is driven by accelerated glycolysis, independently of oxygen
levels, which results in increased lactate production. Lactate is shuttled to and from cancer …