Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …

Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

The lateral parabrachial nucleus (lPBN) is a major target of spinal projection neurons
conveying nociceptive input into supraspinal structures. However, the functional role of …

Opioids are the most effective drugs for the treatment of severe pain, but they also cause
addiction and overdose deaths, which have led to a worldwide opioid crisis. Therefore, the …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

Background Notalgia paresthetica is a neuropathic disorder characterized by pruritus in a
circumscribed region of the upper back. Difelikefalin, a selective kappa opioid receptor …

Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and
chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron …

The field of research on pain originating from various bone diseases is expanding rapidly,
with new mechanisms and targets asserting both peripheral and central sites of action. The …

Introduction There is an unmet medical need for pruritus associated with chronic kidney
disease, a distressing complication characterized by generalized and persistent itch …