Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million
men and women living in the United States are diagnosed with colorectal cancer, with a …

The gastrointestinal tract is exposed to pro-oxidants from food, host immune factors, and
microbial pathogens, which may induce oxidative damage. Oxidative stress has been shown …

Objective The aim of this study was to review the literature to assess if there is evidence to
support the use of Curcumin as a safe complementary therapy in treating Crohn's Disease …

Colorectal cancer (CRC) is commonly known as one of the most prominent reasons for
cancer‐related death in China. Ras homolog enriched in brain (RHEB) and the mammalian …

We performed gene expression microarray analysis coupled with spherical self-organizing
map (sSOM) for artificially developed cancer stem cells (CSCs). The CSCs were developed …

KRAS mutations are the most common oncogenic mutations in lung adenocarcinoma in
Black Americans. Polyisoprenylated Cysteinyl amide Inhibitors (PCAIs) constitute a group of …

The flexible C-terminal hypervariable region distinguishes K-Ras4B, an important proto-
oncogenic GTPase, from other Ras GTPases. This unique lysine-rich portion of the protein …

Post-translational modifications (PTMs) of proteins contribute to the occurrence and
development of tumors. Previous studies have suggested that canonical PTMs such as …

Pancreatic cancer is the most deadly neoplasm with a 5-year survival rate of less than 6%.
Over 90% of cases harbor K-Ras mutations, which are the most challenging to treat due to …

The involvement of hyperactive polyisoprenylated proteins in cancers has stimulated the
search for drugs to target and suppress their excessive activities. Polyisoprenylated …