Abstract Mitochondria-associated membranes (MAM), physical platforms that enable
communication between mitochondria and the endoplasmic reticulum (ER), are enriched …

Defective mitophagy is causally linked to obesity complications. Here, we identified an
interaction between mitophagy protein FUNDC1 (FUN14 domain containing 1) and receptor …

Ca 2+ signaling governs a diverse range of cellular processes and, as such, is subject to
tight regulation. A main component of the complex intracellular Ca 2+-signaling network is …

Background: Platelets can support cancer progression via the release of microparticles and
microvesicles that enhance the migratory behaviour of recipient cancer cells. We recently …

Hepatocellular carcinoma (HCC) is an aggressive cancer histotype and one of the most
common types of cancer worldwide. The identification of compounds that might intervene to …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer related death worldwide. Its diagnosis at early stages would significantly improve the …

Inter-organellar contact sites establish microdomains for localised Ca 2+-signalling events.
One of these microdomains is established between the ER and the mitochondria …

Ca2+ is an integral mediator of intracellular signaling, impacting almost every aspect of
cellular life. The Ca2+-conducting transporters located on the endoplasmic reticulum (ER) …

Cell morphology is altered in the migration process, and the underlying cytoskeleton
remodeling is highly dependent of intracellular Ca 2+ concentration. Many calcium channels …

Although the elixir of youth remains in the darkness, medical and scientific advances have
succeeded in increasing human longevity; however, the predisposition to disease and its …