Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …

Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

The identity of cellular populations that drive liver regeneration after injury is the subject of
intense study, and the contributions of polyploid hepatocytes to organ regeneration and …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Post-zygotic variation refers to genetic changes that arise in the soma of an individual and
that are not usually inherited by the next generation. Although there is a paucity of research …

Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest
that∼ 37% of human tumors have undergone a genome-doubling event during their …

Defining how organ size is regulated, a process controlled not only by the number of cells
but also by the size of the cells, is a frontier in developmental biology. Large cells are …

Bursts of nascent mRNA have been shown to lead to substantial cell-cell variation in
unicellular organisms, facilitating diverse responses to environmental challenges. It is …

Polyploidization is one of the most dramatic changes that can occur in the genome. In the
liver, physiological polyploidization events occur during both liver development and …

Chronic liver disease and primary liver cancer are a massive global problem, with a future
increase in incidences predicted. The most prevalent form of primary liver cancer …