This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on
the central nervous system, particularly on brain regions such as the ventrolateral medulla …

Significance: There is now compelling evidence to substantiate the notion that by
depressing baroreflex regulation of blood pressure and augmenting central sympathetic …

Background In addition to systemic inflammation, neuroinflammation in the brain, which
enhances sympathetic drive, plays a significant role in cardiovascular diseases, including …

Several pieces of evidence indicate that the rostral ventrolateral medulla (RVLM) is probably
one of the key neural structures mediating the pressor effects of orexins in the brain. Nitric …

The present study examined the role of inducible nitric oxide synthase (iNOS) in the rostral
ventrolateral medulla (RVLM) of the brain stem, where the vasomotor center is located, in …

Sympathoexcitation has an important role in the pathogenesis of hypertension. Previous
studies have demonstrated that nitric oxide (NO) and/or oxidative stress in the brain are …

Background—Overproduction of nitric oxide (NO) by inducible NO synthase (iNOS) in the
rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located …

The “programming hypothesis” proposes that an adverse perinatal milieu leads to
adaptation that translates into cardiovascular disease in adulthood. The balance between …

Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic
inhibitory (nitrergic) nerves, and heart plays important roles in the control of blood pressure …

The role of short-chain fatty acids (SCFAs) in the brain on the developmental programming
of hypertension is poorly understood. The present study explored dysregulated tissue levels …