Defective HIV-1 genomes and their potential impact on HIV pathogenesis
J Kuniholm, C Coote, AJ Henderson - Retrovirology, 2022 - Springer
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …
Human monocyte-derived microglia-like cell models: A review of the benefits, limitations and recommendations
TJ Sargeant, C Fourrier - Brain, Behavior, and Immunity, 2023 - Elsevier
In the last few decades, mounting evidence has highlighted that microglia have crucial roles
in both health and disease. This has led to a growing interest in studying human microglia in …
in both health and disease. This has led to a growing interest in studying human microglia in …
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages
N 6-methyladenosine (m6A) is a prevalent RNA modification that plays a key role in
regulating eukaryotic cellular mRNA functions. RNA m6A modification is regulated by two …
regulating eukaryotic cellular mRNA functions. RNA m6A modification is regulated by two …
HIV transcription persists in the brain of virally suppressed people with HIV
J Jamal Eddine, TA Angelovich, J Zhou… - PLoS …, 2024 - journals.plos.org
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated
neurocognitive disorders. Whether HIV transcription persists in the brain despite viral …
neurocognitive disorders. Whether HIV transcription persists in the brain despite viral …
[HTML][HTML] Tools for studying human microglia: In vitro and in vivo strategies
Microglia may only represent 10% of central nervous system (CNS) cells but they perform
critical roles in development, homeostasis and neurological disease. Microglia are also …
critical roles in development, homeostasis and neurological disease. Microglia are also …
Lessons for understanding central nervous system HIV reservoirs from the last gift program
PK Riggs, A Chaillon, G Jiang, SL Letendre… - Current HIV/AIDS …, 2022 - Springer
Abstract Purpose of Review Deep tissue HIV reservoirs, especially within the central
nervous system (CNS), are understudied due to the challenges of sampling brain, spinal …
nervous system (CNS), are understudied due to the challenges of sampling brain, spinal …
Dodging the host interferon-stimulated gene mediated innate immunity by HIV-1: a brief update on intrinsic mechanisms and counter-mechanisms
K Chintala, K Mohareer, S Banerjee - Frontiers in Immunology, 2021 - frontiersin.org
Host restriction factors affect different phases of a viral life cycle, contributing to innate
immunity as the first line of defense against viruses, including HIV-1. These restriction factors …
immunity as the first line of defense against viruses, including HIV-1. These restriction factors …
The discovery and development of RNA-based therapies for treatment of HIV-1 infection
MJ Chen, A Gatignol… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Long-term control of HIV-1 infection can potentially be achieved using
autologous stem cell transplants with gene-modified cells. Non-coding RNAs represent a …
autologous stem cell transplants with gene-modified cells. Non-coding RNAs represent a …
HIV-1-induced type I IFNs promote viral latency in macrophages
Macrophages chronically infected with HIV-1 serve as a reservoir that contributes to HIV-1
persistence during antiretroviral therapy; however, the mechanisms governing the …
persistence during antiretroviral therapy; however, the mechanisms governing the …
The splice of life: does RNA processing have a role in HIV-1 persistence?
AO Pasternak, B Berkhout - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus.
Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main …
Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main …