Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …

Tyrosine kinases (TKs) are involved in key signaling events/pathways that regulate cancer
cell proliferation, apoptosis, angiogenesis and metastasis. Deregulated activity of TKs has …

Nilotinib, a BCR-Abl tyrosine kinase inhibitor (TKI), was developed to surmount resistance or
intolerance to imatinib in patients with Philadelphia positive chronic myelogenous leukemia …

Sildenafil is a potent and selective inhibitor of the type 5 cGMP (cyclic guanosine 3′, 5′-
monophosphate)-specific phosphodiesterase that is used clinically to treat erectile …

A panel of clinically used tyrosine kinase inhibitors were compared and nilotinib was found
to most potently sensitize specific anticancer agents by blocking the functions of ABCB1/P …

TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we
investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation …

Colorectal cancer is the third most common human cancer with frequent overexpression of
the cGMP-specific phosphodiesterase 5 (PDE5). In the present study, we investigated that …

Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …

MET receptor has emerged as a druggable target across several human cancers. Agents
targeting MET and its ligand hepatocyte growth factor (HGF) including small molecules such …

The superfamily of human ATP-binding cassette (ABC) transporters comprises seven
subfamilies (ABCA to G) with 48 members. In addition to their profound physiological and …