Amino acid metabolism in health and disease
ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. An Official American Thoracic Society Research Statement
Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …
syndromes is a significant determinant of short-and long-term outcomes. Although …
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the …
hypertension (PH). However, the mechanisms by which biophysical properties of the …
The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure
The right ventricle (RV) is the major determinant of functional state and prognosis in
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
Metabolism in pulmonary hypertension
W Xu, AJ Janocha, SC Erzurum - Annual review of physiology, 2021 - annualreviews.org
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension
T Thenappan, SY Chan… - American Journal of …, 2018 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the extracellular
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …
The role for Myc in coordinating glycolysis, oxidative phosphorylation, glutaminolysis, and fatty acid metabolism in normal and neoplastic tissues
ES Goetzman, EV Prochownik - Frontiers in endocrinology, 2018 - frontiersin.org
That cancer cells show patterns of metabolism different from normal cells has been known
for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits …
for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits …
The Emerging Role of l-Glutamine in Cardiovascular Health and Disease
W Durante - Nutrients, 2019 - mdpi.com
Emerging evidence indicates that l-glutamine (Gln) plays a fundamental role in
cardiovascular physiology and pathology. By serving as a substrate for the synthesis of …
cardiovascular physiology and pathology. By serving as a substrate for the synthesis of …
Plasma metabolomics implicates modified transfer RNAs and altered bioenergetics in the outcomes of pulmonary arterial hypertension
CJ Rhodes, P Ghataorhe, J Wharton… - Circulation, 2017 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high
mortality. Methods: We conducted a comprehensive study of plasma metabolites using …
mortality. Methods: We conducted a comprehensive study of plasma metabolites using …