Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Key points Although antioxidant supplements are generally believed to give health benefits,
recent experiments show that they may adversely affect adaptations to endurance exercise …

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which are commonly found in fish oil
supplements, are known to possess anti-inflammatory properties and more recently alter …

Overactivation of the renin–angiotensin (Ang) system (RAS) increases the classical arm
(Ang-converting enzyme (ACE)/Ang II/Ang type 1 receptor (AT1R)) to the detriment of the …

The plasticity of skeletal muscle, whether an increase in size, change in metabolism, or
alteration in structural properties, is in a continuous state of flux largely dependent upon …

Increased aerobic exercise capacity, as a result of exercise training, has important health
benefits. However, some individuals are resistant to improvements in exercise capacity …

The serine/threonine kinase mammalian target of rapamycin (mTOR) is the catalytic subunit
of two complexes, mTORC1 and mTORC2, which have common and distinct subunits that …

From the discovery of ATP and motor proteins to synaptic neurotransmitters and growth
factor control of cell differentiation, skeletal muscle has provided an extreme model system …

Abstract mTORC1 is an important regulator of muscle mass but how it is modulated by
oxygen and nutrients is not completely understood. We show that loss of the prolyl …