The increasing demand for functional materials and an efficient use of sustainable resources
makes the search for new material systems an ever growing endeavor. With this respect …

Spheroids are multicellular systems with an interesting rheology giving rise to elasto-visco-
plastic properties. They are good tumor models, but the role of the extracellular matrix (ECM) …

Current clinical methods of bone health assessment depend to a great extent on bone
mineral density (BMD) measurements. However, these methods only act as a proxy for bone …

Preclinical studies often require animal models for in vivo experiments. Particularly in dental
research, pig species are extensively used due to their anatomical similarity to humans …

The hierarchical design of bio-based nanostructured materials such as bone enables them
to combine unique structure-mechanical properties. As one of its main components, water …

Mineralized collagen fibril (MCF) arrays are important structural elements involved in
inelastic deformation and fracture process of bone. Recent experiments have shown that …

Although collagen-mineral sliding is recognized as one of the intrinsic mechanisms that
contribute to the bone toughness, its precise role in energy release at the nano-scale, as …

Mechanical heterogeneity refers to the spatial inhomogeneity of the mechanical properties
in materials, which is a common feature of composites consisting of multiple distinct phases …