Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Resveratrol and Alzheimer's disease: mechanistic insights

T Ahmed, S Javed, S Javed, A Tariq, D Šamec… - Molecular …, 2017 - Springer
Alzheimer's disease (AD) is the leading cause of dementia in the elderly and is
characterized by progressive cognitive and memory deficits. The pathological hallmarks of …

Resveratrol attenuates oxidative stress‐induced intestinal barrier injury through PI3K/Akt‐mediated Nrf2 signaling pathway

Y Zhuang, H Wu, X Wang, J He, S He… - Oxidative medicine and …, 2019 - Wiley Online Library
Oxidative stress is implicated in a wide range of intestinal disorders and closely associated
with their pathological processes. Resveratrol (RSV), a plant extract, plays a vital role in …

Nutrients in the Prevention of Alzheimer's Disease

AL Cremonini, I Caffa, M Cea… - Oxidative medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a disease caused by the complex interaction of multiple
mechanisms, some of which are still not fully understood. To date, pharmacological …

Resveratrol brain delivery for neurological disorders prevention and treatment

S Andrade, MJ Ramalho, MC Pereira… - Frontiers in …, 2018 - frontiersin.org
Resveratrol (RES) is a natural polyphenolic non-flavonoid compound present in grapes,
mulberries, peanuts, rhubarb and in several other plants. Numerous health effects have …

Resveratrol, a neuroprotective supplement for Alzheimer's disease

F Li, Q Gong, H Dong, J Shi - Current pharmaceutical design, 2012 - ingentaconnect.com
The polyphenolic compound resveratrol (3, 4', 5-trihydroxystilbene) is a naturally occurring
phytochemical which has been found in more than 70 plant species, including herbs and …

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

MR Ramis, S Esteban, A Miralles, DX Tan… - Mechanisms of ageing …, 2015 - Elsevier
Aging is an inevitable and multifactorial biological process. Free radicals have been
implicated in aging processes; it is hypothesized that they cause cumulative oxidative …

Considerations for the use of polyphenols as therapies in neurodegenerative diseases

J Renaud, MG Martinoli - International Journal of Molecular Sciences, 2019 - mdpi.com
Over the last two decades, the increase in the incidence of neurodegenerative diseases due
to the increasingly ageing population has resulted in a major social and economic burden …

Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models

N Singh, M Agrawal, S Doré - ACS chemical neuroscience, 2013 - ACS Publications
Resveratrol, a natural stilbene present at relatively high concentrations in grape skin and
seeds and red wine, is known for its purported antioxidant activity in the vascular and …

Role of melatonin in the inflammatory process and its therapeutic potential

L Carrascal, P Nunez-Abades, A Ayala… - Current …, 2018 - ingentaconnect.com
Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …