Bone metastasis: mechanisms and therapeutic opportunities

LJ Suva, C Washam, RW Nicholas… - Nature Reviews …, 2011 - nature.com
The skeleton is one of the most common sites for metastatic cancer, and tumors arising from
the breast or prostate possess an increased propensity to spread to this site. The growth of …

Gene-environment interactions in the skeletal response to nutrition and exercise during growth

JP Bonjour, T Chevalley, R Rizzoli… - Optimizing Bone Mass and …, 2007 - karger.com
The amount of bone mineral mass acquired at the end of growth, the so-called 'peak bone
mass', is considered to be a major risk factor for the occurrence of fragility fractures during …

[图书][B] Biomechanics of musculoskeletal injury

WC Whiting, RF Zernicke - 2008 - books.google.com
Biomechanics of Musculoskeletal Injury, Second Edition, presents clear, accessible
explanations of the biomechanical principles of injury and how injuries affect the normal …

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response

GJ Atkins, KJ Welldon, P Halbout, DM Findlay - Osteoporosis International, 2009 - Springer
The effect of strontium ranelate (SR) on human osteoblast differentiation was tested. SR
induced osteoblastic proliferation, in vitro mineralization, and increased the expression of …

Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling …

X Chen, J Yan, F He, D Zhong, H Yang, M Pei… - Free Radical Biology …, 2018 - Elsevier
Mesenchymal stem cells (MSCs) are promising cell sources for regenerative medicine.
Growing evidence has indicated that mechanical stimuli are crucial for their lineage-specific …

Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by γ-carboxylation-dependent and-independent mechanisms

GJ Atkins, KJ Welldon… - … of Physiology-Cell …, 2009 - journals.physiology.org
The vitamin K family members phylloquinone (vitamin K1) and the menaquinones (vitamin
K2) are under study for their roles in bone metabolism and as potential therapeutic agents …

Role of angiocrine signals in bone development, homeostasis and disease

U Sivan, J De Angelis, AP Kusumbe - Open Biology, 2019 - royalsocietypublishing.org
Skeletal vasculature plays a central role in the maintenance of microenvironments for
osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients …

[HTML][HTML] Decreased osteogenesis of adult mesenchymal stem cells by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis

J Tan, X Xu, Z Tong, Q Yu, Y Lin, W Kuang - Bone research, 2015 - nature.com
Age related defect of the osteogenic differentiation of mesenchymal stem cells (MSCs) plays
a key role in osteoporosis. Mechanical loading is one of the most important physical stimuli …

Effect of bariatric surgery on bone mineral density: comparison of gastric bypass and sleeve gastrectomy

N Vilarrasa, AGR de Gordejuela, C Gómez-Vaquero… - Obesity surgery, 2013 - Springer
The aim of our study was to compare bone mineral density (BMD) a year after Roux-en-Y
gastric bypass (RYGB) and sleeve gastrectomy (SG) in age-and body mass index-matched …

Physical activity and bone: The importance of the various mechanical stimuli for bone mineral density. A review

B Morseth, N Emaus, L Jørgensen - Norsk epidemiologi, 2011 - ntnu.no
Numerous studies have reported benefits of regular physical activity on bone mineral
density (BMD). The effects of physical activity on BMD are primarily linked to the …