Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

Schizophrenia is a highly debilitating mental disorder that affects∼ 1% of the general
population, yet it continues to be poorly understood. Recent studies have identified …

The β‐site APP cleaving enzymes 1 and 2 (BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …

The activity-dependent regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA)-type glutamate receptors and the stabilization of synapses are critical to synaptic …

Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on
chromosome 8p shows linkage to the disorder, and genetic association has been found …

Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …

The myelin sheath wraps large axons in both the CNS and the PNS, and is a key
determinant of efficient axonal function and health. Myelin is targeted in a series of diseases …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …

Rationale: Neuregulin-1 (NRG-1) includes an extracellular epidermal growth factor–like
domain and an intracellular domain (NRG-1-ICD). In response to transforming growth factor …