Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
The many substrates of presenilin/γ-secretase
A Haapasalo, DM Kovacs - Journal of Alzheimer's disease, 2011 - content.iospress.com
The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Schizophrenia is a highly debilitating mental disorder that affects∼ 1% of the general
population, yet it continues to be poorly understood. Recent studies have identified …
population, yet it continues to be poorly understood. Recent studies have identified …
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
R Vassar, PH Kuhn, C Haass… - Journal of …, 2014 - Wiley Online Library
The β‐site APP cleaving enzymes 1 and 2 (BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …
PSD-95 is required for activity-driven synapse stabilization
The activity-dependent regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA)-type glutamate receptors and the stabilization of synapses are critical to synaptic …
(AMPA)-type glutamate receptors and the stabilization of synapses are critical to synaptic …
Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology
PJ Harrison, AJ Law - Biological psychiatry, 2006 - Elsevier
Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on
chromosome 8p shows linkage to the disorder, and genetic association has been found …
chromosome 8p shows linkage to the disorder, and genetic association has been found …
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1–ErbB4 and DISC1
H Jaaro-Peled, A Hayashi-Takagi, S Seshadri… - Trends in …, 2009 - cell.com
Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …
by susceptibility genes and environmental insults during early neurodevelopment initiate …
Signals to promote myelin formation and repair
The myelin sheath wraps large axons in both the CNS and the PNS, and is a key
determinant of efficient axonal function and health. Myelin is targeted in a series of diseases …
determinant of efficient axonal function and health. Myelin is targeted in a series of diseases …
Neuregulin-1/ErbB network: An emerging modulator of nervous system injury and repair
Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …
A novel regulatory mechanism of smooth muscle α-actin expression by NRG-1/circACTA2/miR-548f-5p axis
Y Sun, Z Yang, B Zheng, X Zhang, M Zhang… - Circulation …, 2017 - Am Heart Assoc
Rationale: Neuregulin-1 (NRG-1) includes an extracellular epidermal growth factor–like
domain and an intracellular domain (NRG-1-ICD). In response to transforming growth factor …
domain and an intracellular domain (NRG-1-ICD). In response to transforming growth factor …