Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Deep brain stimulation targets in epilepsy: systematic review and meta‐analysis of anterior and centromedian thalamic nuclei and hippocampus

A Vetkas, A Fomenko, J Germann, C Sarica… - …, 2022 - Wiley Online Library
Deep brain stimulation (DBS) is a neuromodulatory treatment used in patients with drug‐
resistant epilepsy (DRE). The primary goal of this systematic review and meta‐analysis is to …

Practical considerations in epilepsy neurostimulation

HD Simpson, A Schulze‐Bonhage, GD Cascino… - …, 2022 - Wiley Online Library
Neuromodulation is a key therapeutic tool for clinicians managing patients with drug‐
resistant epilepsy. Multiple devices are available with long‐term follow‐up and real‐world …

Seizure forecasting: bifurcations in the long and winding road

MO Baud, T Proix, NM Gregg, BH Brinkmann… - …, 2023 - Wiley Online Library
To date, the unpredictability of seizures remains a source of suffering for people with
epilepsy, motivating decades of research into methods to forecast seizures. Originally, only …

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

NM Gregg, V Sladky, P Nejedly, F Mivalt, I Kim… - Scientific reports, 2021 - nature.com
Chronic brain recordings suggest that seizure risk is not uniform, but rather varies
systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human …

Patient‐specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy

CM Charlebois, DN Anderson, KA Johnson… - …, 2022 - Wiley Online Library
Objective Responsive neurostimulation is an effective therapy for patients with refractory
mesial temporal lobe epilepsy. However, clinical outcomes are variable, few patients …

Distributed brain co-processor for tracking spikes, seizures and behaviour during electrical brain stimulation

V Sladky, P Nejedly, F Mivalt… - Brain …, 2022 - academic.oup.com
Early implantable epilepsy therapy devices provided open-loop electrical stimulation without
brain sensing, computing, or an interface for synchronized behavioural inputs from patients …

Proceedings of the ninth annual deep brain stimulation think tank: advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, pain …

JK Wong, G Deuschl, R Wolke, H Bergman… - Frontiers in Human …, 2022 - frontiersin.org
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based
participants largely in person and overseas participants joining by video conferencing …

Chronic electroencephalography in epilepsy with a responsive neurostimulation device: current status and future prospects

VR Rao - Expert Review of Medical Devices, 2021 - Taylor & Francis
Introduction Implanted neurostimulation devices are gaining traction as therapeutic options
for people with certain forms of drug-resistant focal epilepsy. Some of these devices enable …

Sensing with deep brain stimulation device in epilepsy: Aperiodic changes in thalamic local field potential during seizures

AI Yang, ALB Raghu, F Isbaine, A Alwaki, RE Gross - Epilepsia, 2023 - Wiley Online Library
Objective Thalamic deep brain stimulation (DBS) is an effective therapeutic option in
patients with drug‐resistant epilepsy. Recent DBS devices with sensing capabilities enable …