Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
RK Jain - Journal of Clinical Oncology, 2013 - ascopubs.org
For almost four decades, my work has focused on one challenge: improving the delivery and
efficacy of anticancer therapeutics. Working on the hypothesis that the abnormal tumor …
efficacy of anticancer therapeutics. Working on the hypothesis that the abnormal tumor …
Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo
Light is used extensively in biological and medical research for optogenetic
neuromodulation, fluorescence imaging, photoactivatable gene editing and light-based …
neuromodulation, fluorescence imaging, photoactivatable gene editing and light-based …
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-
associated cancer, but most develops in patients without underlying inflammatory bowel …
associated cancer, but most develops in patients without underlying inflammatory bowel …
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
P Carmeliet, RK Jain - Nature reviews Drug discovery, 2011 - nature.com
Despite having an abundant number of vessels, tumours are usually hypoxic and nutrient-
deprived because their vessels malfunction. Such abnormal milieu can fuel disease …
deprived because their vessels malfunction. Such abnormal milieu can fuel disease …
Normalization of the vasculature for treatment of cancer and other diseases
New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre‐clinical models
Microcirculation (2010) 17, 206–225. doi: 10.1111/j. 1549‐8719.2010. 00029. x Abstract
Intravital imaging techniques have provided unprecedented insight into tumor …
Intravital imaging techniques have provided unprecedented insight into tumor …
Bioabsorbable polymer optical waveguides for deep-tissue photomedicine
Advances in photonics have stimulated significant progress in medicine, with many
techniques now in routine clinical use. However, the finite depth of light penetration in tissue …
techniques now in routine clinical use. However, the finite depth of light penetration in tissue …
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as
tumors rapidly develop resistance to these agents. Here, we have uncovered an …
tumors rapidly develop resistance to these agents. Here, we have uncovered an …
Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts
Rationale: High-resolution imaging of the heart in vivo is challenging owing to the difficulty in
accessing the heart and the tissue motion caused by the heartbeat. Objective: Here, we …
accessing the heart and the tissue motion caused by the heartbeat. Objective: Here, we …
What does physics have to do with cancer?
F Michor, J Liphardt, M Ferrari, J Widom - Nature Reviews Cancer, 2011 - nature.com
Large-scale cancer genomics, proteomics and RNA-sequencing efforts are currently
mapping in fine detail the genetic and biochemical alterations that occur in cancer. However …
mapping in fine detail the genetic and biochemical alterations that occur in cancer. However …