Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …

Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Transcription factor EB (TFEB) is considered the master transcriptional regulator of
autophagy and lysosomal biogenesis, which regulates target gene expression through …

Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post‑translational modifications (PTMs). The …

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder, which is
characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular …

Two decades ago, the recognition of protein misfolding and aggregate accumulation as
defining features of neurodegenerative disease set the stage for a thorough examination of …

Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the
regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative …