Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies

L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches

TB Emran, A Shahriar, AR Mahmud, T Rahman… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells

U Testa, G Castelli, E Pelosi - Cancers, 2018 - mdpi.com
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC

HP Mohammad, KN Smitheman, CD Kamat, D Soong… - Cancer cell, 2015 - cell.com
Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in
epigenetic machinery have become a major focus for targeted therapies. The current report …

Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches

Q Wu, Z Yang, Y Nie, Y Shi, D Fan - Cancer letters, 2014 - Elsevier
Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer
chemotherapies. The mechanisms of MDR and the approaches to test MDR have been …

New insights into small‐cell lung cancer development and therapy

Y Wang, S Zou, Z Zhao, P Liu, C Ke… - Cell Biology …, 2020 - Wiley Online Library
Small‐cell lung cancer (SCLC) accounts for approximately 15% of lung cancer cases;
however, it is characterized by easy relapse and low survival rate, leading to one of the most …

[HTML][HTML] The role of stem cells in small-cell lung cancer: evidence from chemoresistance to immunotherapy

W Guo, T Qiao, T Li - Seminars in Cancer Biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer, accounting for
approximately 15% among all lung cancers. Despite the ability of chemotherapy, the first …

Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways

G Leon, L MacDonagh, SP Finn, S Cuffe… - Pharmacology & …, 2016 - Elsevier
Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-
cancer therapies such as chemotherapy, radiotherapy and targeted therapies, five-year …

(−)-Epigallocatechin Gallate (EGCG) enhances the sensitivity of colorectal cancer cells to 5-FU by inhibiting GRP78/NF-κB/miR-155-5p/MDR1 pathway

X La, L Zhang, Z Li, H Li, Y Yang - Journal of agricultural and food …, 2019 - ACS Publications
Green tea accounts for approximately 20% of the world's total tea yield.(−)-Epigallocatechin
gallate (EGCG) is an active catechin in green tea, which suppresses tumor growth and …

Small cell lung cancer screen of oncology drugs, investigational agents, and gene and microRNA expression

E Polley, M Kunkel, D Evans, T Silvers… - Journal of the …, 2016 - academic.oup.com
Background: Small cell lung carcinoma (SCLC) is an aggressive, recalcitrant cancer, often
metastatic at diagnosis and unresponsive to chemotherapy upon recurrence, thus it is …