Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Inflammation is a natural process that is connected to various conditions and disorders such
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …

The development of orthogonal Csp2–Csp2 coupling regimes to the omnipresent Pd-
catalysis class would enable an additional dimension of modularity in the construction of …

Imidazole remains a privileged heterocycle in drug discovery. Imidazole scaffold is a
ubiquitous motif that is present in several pharmacologically important drug molecules such …

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that
exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations …

A new series of 2-(5-aryl-1-phenyl-1 H-pyrazol-3-yl)-4-aryl thiazoles (10a–ab) have been
synthesized by a cyclocondensation reaction of 5-aryl-1-phenyl-1 H-pyrazole-3 …

Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a–e, and 5a–e were
synthesised. Different biological activities of the synthesised compounds were studied …

Over the last few decades, a growing body of studies addressed the anticancer activity of
NSAIDs, particularly selective COX-2 inhibitors. However, their exact molecular mechanism …

Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins,
whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide …

This work reports the classification study conducted on the biggest COX-2 inhibitor data set
so far. Using 2925 diverse COX-2 inhibitors collected from 168 pieces of literature, we …