Intrinsically disordered proteins: an overview
R Trivedi, HA Nagarajaram - International journal of molecular sciences, 2022 - mdpi.com
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …
The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease
MM Babu - Biochemical Society Transactions, 2016 - portlandpress.com
In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a
protein is determined by its amino acid sequence. This work laid the foundation for the …
protein is determined by its amino acid sequence. This work laid the foundation for the …
[HTML][HTML] Conformational entropy in molecular recognition of intrinsically disordered proteins
Broad conformational ensembles make intrinsically disordered proteins or regions
entropically intriguing. Although methodologically challenging and understudied, emerging …
entropically intriguing. Although methodologically challenging and understudied, emerging …
Markov state models provide insights into dynamic modulation of protein function
Conspectus Protein function is inextricably linked to protein dynamics. As we move from a
static structural picture to a dynamic ensemble view of protein structure and function, novel …
static structural picture to a dynamic ensemble view of protein structure and function, novel …
ALS-causing mutations significantly perturb the self-assembly and interaction with nucleic acid of the intrinsically disordered prion-like domain of TDP-43
TAR-DNA-binding protein-43 (TDP-43) C-terminus encodes a prion-like domain widely
presented in RNA-binding proteins, which functions to form dynamic oligomers and also …
presented in RNA-binding proteins, which functions to form dynamic oligomers and also …
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
S Liénart, R Merceron, C Vanderaa, F Lambert… - Science, 2018 - science.org
Transforming growth factor–β1 (TGF-β1) is one of very few cytokines produced in a latent
form, requiring activation to exert any of its vastly diverse effects on development, immunity …
form, requiring activation to exert any of its vastly diverse effects on development, immunity …
[HTML][HTML] On the potential of machine learning to examine the relationship between sequence, structure, dynamics and function of intrinsically disordered proteins
K Lindorff-Larsen, BB Kragelund - Journal of Molecular Biology, 2021 - Elsevier
Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
Eukaryotic transcription factors: paradigms of protein intrinsic disorder
Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …
pathways, controlling, for example, cell growth, development, and stress responses. Their …
Expanding the paradigm: intrinsically disordered proteins and allosteric regulation
RB Berlow, HJ Dyson, PE Wright - Journal of molecular biology, 2018 - Elsevier
Allosteric regulatory processes are implicated at all levels of biological function. Recent
advances in our understanding of the diverse and functionally significant class of intrinsically …
advances in our understanding of the diverse and functionally significant class of intrinsically …