Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …

In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a
protein is determined by its amino acid sequence. This work laid the foundation for the …

Broad conformational ensembles make intrinsically disordered proteins or regions
entropically intriguing. Although methodologically challenging and understudied, emerging …

Conspectus Protein function is inextricably linked to protein dynamics. As we move from a
static structural picture to a dynamic ensemble view of protein structure and function, novel …

TAR-DNA-binding protein-43 (TDP-43) C-terminus encodes a prion-like domain widely
presented in RNA-binding proteins, which functions to form dynamic oligomers and also …

Transforming growth factor–β1 (TGF-β1) is one of very few cytokines produced in a latent
form, requiring activation to exert any of its vastly diverse effects on development, immunity …

Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …

Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …

Allosteric regulatory processes are implicated at all levels of biological function. Recent
advances in our understanding of the diverse and functionally significant class of intrinsically …