Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Loss of skeletal integrity during ageing and disease is associated with an imbalance in the
opposing actions of osteoblasts and osteoclasts. Here we show that intrinsic ageing of …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Mesenchymal stem cells (MSCs) reside in microenvironments, referred to as niches, which
provide structural support and molecular signals. Sensory nerves are niche components in …

Human embryonic bone and joint formation is determined by coordinated differentiation of
progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory …

With very few exceptions, all adult tissues in mammals are maintained and can be renewed
by stem cells that self-renew and generate the committed progeny required. These functions …

Since its discovery 150 years ago, the neural crest has intrigued investigators owing to its
remarkable developmental potential and extensive migratory ability. Cell lineage analysis …

Abstract Purpose of Review Here, we discuss the origin of chondrocytes, their destiny, and
their plasticity in relationship to bone growth, articulation, and formation of the trabeculae …

The tissue-resident skeletal stem cells (SSCs), which are self-renewal and multipotent,
continuously provide cells (including chondrocytes, bone cells, marrow adipocytes, and …