Molecular mechanisms and emerging therapeutics for osteoporosis
JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …
that more than 10 million people in the United States and 200 million men and women …
Review of signaling pathways governing MSC osteogenic and adipogenic differentiation
AW James - Scientifica, 2013 - Wiley Online Library
Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …
Role of YAP/TAZ in cell lineage fate determination and related signaling pathways
BC Heng, X Zhang, D Aubel, Y Bai, X Li… - Frontiers in cell and …, 2020 - frontiersin.org
The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …
co-activator proteins that play key roles in many diverse biological processes, ranging from …
The osteoprotective effects of kaempferol: the evidence from in vivo and in vitro studies
Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It
possesses a wide range of medicinal properties suggesting its potential clinical utility that …
possesses a wide range of medicinal properties suggesting its potential clinical utility that …
Inflammation, mesenchymal stem cells and bone regeneration
H Liu, D Li, Y Zhang, M Li - Histochemistry and cell biology, 2018 - Springer
Achieving satisfactory reconstruction of bone remains an important goal in orthopedic and
dental conditions such as bone trauma, osteoporosis, arthritis, osteonecrosis, and …
dental conditions such as bone trauma, osteoporosis, arthritis, osteonecrosis, and …
Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-κB and MAPK signaling pathways
R Zhang, X Ai, Y Duan, M Xue, W He, C Wang… - Biomedicine & …, 2017 - Elsevier
Kaempferol, a very common type of dietary flavonoids, has been found to exert antioxidative
and anti-inflammatory properties. The purpose of our investigation was designed to reveal …
and anti-inflammatory properties. The purpose of our investigation was designed to reveal …
Therapeutic potential and outlook of alternative medicine for osteoporosis
T Wang, Q Liu, W Tjhioe, J Zhao, A Lu… - Current drug …, 2017 - ingentaconnect.com
Osteoporosis, a bone disease resulting in the loss of bone density and microstructure
quality, is often associated with fragility fractures, and the latter imposes a great burden on …
quality, is often associated with fragility fractures, and the latter imposes a great burden on …
Kaempferol ameliorates the inhibitory activity of dexamethasone in the osteogenesis of MC3T3-E1 cells by JNK and p38-MAPK pathways
B Xie, Z Zeng, S Liao, C Zhou, L Wu… - Frontiers in pharmacology, 2021 - frontiersin.org
Kaempferol has been reported to exhibit beneficial effect on the osteogenic differentiation in
mesenchymal stem cells (MSC) and osteoblasts. In our previous study, dexamethasone …
mesenchymal stem cells (MSC) and osteoblasts. In our previous study, dexamethasone …
Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice
X Chen, X Yang, T Liu, M Guan, X Feng, W Dong… - International …, 2012 - Elsevier
Recent studies show that mitogen-activated protein kinases (MAPKs) and nuclear factor-
kappa B (NF-κB) signaling pathways are two pivotal roles contributing to the development of …
kappa B (NF-κB) signaling pathways are two pivotal roles contributing to the development of …
Targeting TLR4 signaling to blunt viral-mediated acute lung injury
KA Shirey, JCG Blanco, SN Vogel - Frontiers in Immunology, 2021 - frontiersin.org
Respiratory viral infections have been a long-standing global burden ranging from seasonal
recurrences to the unexpected pandemics. The yearly hospitalizations from seasonal …
recurrences to the unexpected pandemics. The yearly hospitalizations from seasonal …