[HTML][HTML] Oxidative stress, the immune response, synaptic plasticity, and cognition in transgenic models of Alzheimer disease

PC Bello-Medina, DA González-Franco… - Neurología (english …, 2022 - Elsevier
Introduction Worldwide, approximately 50 million people have dementia, with Alzheimer
disease (AD) being the most common type, accounting for 60%-70% of cases. Given its high …

[HTML][HTML] Spatial memory and gut microbiota alterations are already present in early adulthood in a pre-clinical transgenic model of Alzheimer's disease

PC Bello-Medina, F Hernández-Quiroz… - Frontiers in …, 2021 - frontiersin.org
The irreversible and progressive neurodegenerative Alzheimer's disease (AD) is
characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau …

A distinct parabrachial–to–lateral hypothalamus circuit for motivational suppression of feeding by nociception

SC Phua, YL Tan, AMY Kok, E Senol, CJH Chiam… - Science …, 2021 - science.org
The motivation to eat is not only shaped by nutrition but also competed by external stimuli
including pain. How the mouse hypothalamus, the feeding regulation center, integrates …

Intense inhibitory avoidance training increases nuclear-phosphorylated glucocorticoid receptors in neurons of CA1 of hippocampus and ventral caudate putamen

DA González-Franco, R Pegueros-Maldonado… - Brain Research, 2023 - Elsevier
Corticosterone (CORT), the principal glucocorticoid in rodents, is released after stressful
experiences such as training with high foot-shock intensities in the inhibitory avoidance task …

[HTML][HTML] Estrés oxidativo, respuesta inmune, plasticidad sináptica y cognición en modelos transgénicos de la enfermedad de Alzheimer

PC Bello-Medina, DA González-Franco… - Neurología, 2022 - Elsevier
Introducción En el mundo, alrededor de 50 millones de personas padecen demencia; la
forma más común es la enfermedad de Alzheimer (EA), que representa el 60-70% de los …

Effect of ozone exposure on dendritic spines of CA1 pyramidal neurons of the dorsal hippocampus and on object–place recognition memory in rats

PC Bello-Medina, RA Prado-Alcalá, S Rivas-Arancibia - Neuroscience, 2019 - Elsevier
The growth of many cities has generated an increase in the emission of environmental
pollutants. Exposure to these pollutants has been associated with increased mortality …

Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory

C Siller-Pérez, A Fuentes-Ibañez… - …, 2019 - Elsevier
The endocannabinoid (eCB) system is highly stress sensitive and known to modulate
memory formation of emotionally arousing experiences across different corticolimbic …

[HTML][HTML] Intense training prevents the amnestic effect of inactivation of dorsomedial striatum and induces high resistance to extinction

M Martínez-Degollado, AC Medina, PC Bello-Medina… - Plos one, 2024 - journals.plos.org
A large body of evidence has shown that treatments that interfere with memory consolidation
become ineffective when animals are subjected to an intense learning experience; this effect …

Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies …

K Klinefelter, MK Hooven, C Bates, BT Colter… - Mammalian …, 2018 - Springer
Polychlorinated biphenyls (PCBs) are persistent organic pollutants that remain a human
health concern with newly discovered sources of contamination and ongoing …

[HTML][HTML] Differential phosphorylation of the glucocorticoid receptor in hippocampal subregions induced by contextual fear conditioning training

R Ponce-Lina, N Serafín, M Carranza… - Frontiers in Behavioral …, 2020 - frontiersin.org
Aversive events induce the release of glucocorticoid stress hormones that facilitate long-
term memory consolidation, an effect that depends on the activation of glucocorticoid …