mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR
regulates cell growth and proliferation in response to a wide range of cues, and its signaling …

Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …

TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status …

Cancer cells have a characteristic metabolism, mostly caused by alterations in signal
transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …

The cure rate of osteosarcoma has not improved in the past 30 years. The search for new
treatments and drugs is urgently needed. Apatinib is a high selectivity inhibitor of vascular …

Metformin has been designated as one of the most crucial first-line therapeutic agents in the
management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent …

Background: The anticancer activity of metformin has been confirmed against several cancer
types in vitro and in vivo. However, the underlying mechanisms of metformin in the treatment …