Insulin resistance, the most important characteristic of the type 2 diabetes mellitus (T2DM), is
mostly caused by impairment in the insulin receptor (IR) signal transduction pathway …

Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and
a major risk factor for morbidity and mortality. The abundant cell-free nucleic (DNA/RNA) in …

MicroRNAs (miRNAs) are important regulators of gene expression, and the dysregulation of
miRNAs is a common feature of several diseases. More miRNAs are identified almost daily …

Long noncoding RNAs (lncRNAs) are single‐stranded RNA molecules longer than 200 nt
that regulate many cellular processes. MicroRNA 155 host gene (MIR155HG) encodes the …

Simple Summary Cancer deaths are predominantly due to metastases rather than the
primary tumors, and thus there is an urgent need for the discovery of more effective drug …

Abstract Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family, which
transduces cytokine and growth factor signalling. Analysis of TYK2 loss-of-function revealed …

Type I interferons (IFNs) are among the most powerful tools that host cells deploy against
intracellular pathogens. Their effectiveness is due both to the rapid, directly antiviral effects …

BACKGROUND Dengue is considered one of the world's most important mosquito-borne
diseases. MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that play an …

Lupus nephritis is a potentially reversible cause of severe acute kidney injury and is an
important cause of end-stage renal failure in Asians and patients of African or Hispanic …

In primary Sjögren's syndrome (pSS) the exocrine glands become infiltrated with
lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes …