The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

Rapid reaction to microbes invading mucosal tissues is key to protect the host against
disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity …

Asthma is a chronic disease most commonly associated with allergy and type 2
inflammation. However, the mechanisms that link airway inflammation to the structural …

Allergic diseases are a major global health issue. Interleukin (IL)-9-producing helper T (TH9)
cells promote allergic inflammation, yet TH9 cell effector functions are incompletely …

Abstract T helper 9 (TH9) cells promote allergic tissue inflammation and express the type 2
cytokines, IL-9 and IL-13, as well as the transcription factor, PPAR-γ. However, the functional …

Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion,
limiting adaptive immunity. In contrast, aberrant, sustained T cell responses can persist over …

Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models
suggest that it can promote tumor growth. Here, we show that IL-9 signaling is associated …

Allergic diseases are allergen‐induced immunological disorders characterized by the
development of type 2 immunity and IgE responses. The prevalence of allergic diseases has …

T cells are critical orchestrators of the adaptive immune response that optimally eliminate a
specific pathogen. Aberrant T-cell development and function are implicated in a broad range …

Allergic asthma is a chronic lung disease characterized by airway hyperresponsiveness and
cellular infiltration that is exacerbated by immunoglobulin E-dependent mast cell (MC) …