Treatment of toxoplasmosis: historical perspective, animal models, and current clinical practice

IR Dunay, K Gajurel, R Dhakal… - Clinical microbiology …, 2018 - Am Soc Microbiol
Primary Toxoplasma gondii infection is usually subclinical, but cervical lymphadenopathy or
ocular disease can be present in some patients. Active infection is characterized by …

[HTML][HTML] A systematic review of in vitro and in vivo activities of anti-Toxoplasma drugs and compounds (2006–2016)

M Montazeri, M Sharif, S Sarvi, S Mehrzadi… - Frontiers in …, 2017 - frontiersin.org
The currently available anti-Toxoplasma agents have serious limitations. This systematic
review was performed to evaluate drugs and new compounds used for the treatment of …

Novel Approaches Reveal that Toxoplasma gondii Bradyzoites within Tissue Cysts Are Dynamic and Replicating Entities In Vivo

E Watts, Y Zhao, A Dhara, B Eller, A Patwardhan… - MBio, 2015 - Am Soc Microbiol
Despite their critical role in chronic toxoplasmosis, the biology of Toxoplasma gondii
bradyzoites is poorly understood. In an attempt to address this gap, we optimized …

Hydrolysis of amphenicol and macrolide antibiotics: Chloramphenicol, florfenicol, spiramycin, and tylosin

SM Mitchell, JL Ullman, AL Teel, RJ Watts - Chemosphere, 2015 - Elsevier
Antibiotics that enter the environment can present human and ecological health risks. An
understanding of antibiotic hydrolysis rates is important for predicting their environmental …

Toxoplasma gondii: an underestimated threat?

G Milne, JP Webster, M Walker - Trends in parasitology, 2020 - cell.com
Traditionally, the protozoan parasite Toxoplasma gondii has been thought of as relevant to
public health primarily within the context of congenital toxoplasmosis or postnatally acquired …

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

JP Lanoix, AJ Lenaerts… - Disease models & …, 2015 - journals.biologists.com
Mice are the most commonly used species for non-clinical evaluations of drug efficacy
against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous …

Genome mining of Streptomyces ambofaciens

B Aigle, S Lautru, D Spiteller… - Journal of Industrial …, 2014 - academic.oup.com
Since the discovery of the streptomycin produced by Streptomyces griseus in the middle of
the last century, members of this bacterial genus have been largely exploited for the …

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites

SG Sanchez, E Bassot, A Cerutti… - Proceedings of the …, 2023 - National Acad Sciences
Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when
contracted during pregnancy, but can also be a threat for immunocompromised individuals …

Treatment of toxoplasmosis and neosporosis in farm ruminants: state of knowledge and future trends

R Sánchez-Sánchez, P Vázquez, I Ferre… - Current topics in …, 2018 - ingentaconnect.com
Toxoplasmosis and neosporosis are closely related protozoan diseases that lead to
important economic impacts in farm ruminants. Toxoplasma gondii infection mainly causes …

The powerful synergistic effect of spiramycin/propolis loaded chitosan/alginate nanoparticles on acute murine toxoplasmosis

NA Hagras, NMFH Mogahed, E Sheta… - PLoS Neglected …, 2022 - journals.plos.org
The novel formula of spiramycin/propolis loaded chitosan (CS)/alginate (Alg) nanoparticles
(NPs) was assessed for Toxoplasma gondii (T. gondii) treatment in comparison with the …