[HTML][HTML] Molecular mechanisms of amyloid disaggregation
KJY Low, A Venkatraman, JS Mehta… - Journal of Advanced …, 2022 - Elsevier
Introduction Protein aggregation and deposition of uniformly arranged amyloid fibrils in the
form of plaques or amorphous aggregates is characteristic of amyloid diseases. The …
form of plaques or amorphous aggregates is characteristic of amyloid diseases. The …
The development of peptide-and oligonucleotide-based drugs to prevent the formation of abnormal tau in tauopathies
Introduction Tauopathies represent clinicopathological entities with increased and abnormal
glial and/or neuronal inclusions of tau, a microtubule-binding protein. Antisense …
glial and/or neuronal inclusions of tau, a microtubule-binding protein. Antisense …
Different heat shock proteins bind α-Synuclein with distinct mechanisms and synergistically prevent its amyloid aggregation
α-Synuclein (α-Syn) forms pathological amyloid aggregates deposited in Lewy bodies and
Lewy neurites in the brain of Parkinson's disease (PD) patients. Heat shock proteins (Hsps) …
Lewy neurites in the brain of Parkinson's disease (PD) patients. Heat shock proteins (Hsps) …
Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation
Amyloid aggregation of pathological proteins is closely associated with a variety of
neurodegenerative diseases, and α-synuclein (α-syn) deposition and Tau tangles are …
neurodegenerative diseases, and α-synuclein (α-syn) deposition and Tau tangles are …
Critical molecular and cellular contributors to tau pathology
Tauopathies represent a group of neurodegenerative diseases including Alzheimer's
disease (AD) that are characterized by the deposition of filamentous tau aggregates in the …
disease (AD) that are characterized by the deposition of filamentous tau aggregates in the …
Updates in Alzheimer's disease: from basic research to diagnosis and therapies
E Liu, Y Zhang, JZ Wang - Translational Neurodegeneration, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …
Hsp104 N‐terminal domain interaction with substrates plays a regulatory role in protein disaggregation
A Harari, G Zoltsman, T Levin… - The FEBS …, 2022 - Wiley Online Library
Heat shock protein 104 (Hsp104) protein disaggregases are powerful molecular machines
that harness the energy derived from ATP binding and hydrolysis to disaggregate a wide …
that harness the energy derived from ATP binding and hydrolysis to disaggregate a wide …
Wine yeast cells acquire resistance to severe ethanol stress and suppress insoluble protein accumulation during alcoholic fermentation
M Yoshida, N Furutani, F Imai, T Miki… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT Under laboratory conditions, acute 10%(vol/vol) ethanol stress causes protein
denaturation and accumulation of insoluble proteins in yeast cells. However, yeast cells can …
denaturation and accumulation of insoluble proteins in yeast cells. However, yeast cells can …
From small peptides to large proteins against Alzheimer'sDisease
Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly.
The two cardinal neuropathological hallmarks of AD are the senile plaques, which are …
The two cardinal neuropathological hallmarks of AD are the senile plaques, which are …
Oligomeric state and holding activity of hsp60
C Caruso Bavisotto, A Provenzano… - International Journal of …, 2023 - mdpi.com
Similar to its bacterial homolog GroEL, Hsp60 in oligomeric conformation is known to work
as a folding machine, with the assistance of co-chaperonin Hsp10 and ATP. However …
as a folding machine, with the assistance of co-chaperonin Hsp10 and ATP. However …