Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss
K Hough, CA Verschuur, C Cunningham, TA Newman - Glia, 2022 - Wiley Online Library
Macrophages are abundant in the cochlea; however, their role in hearing loss is not well
understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an …
understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an …
Progress on mechanisms of age-related hearing loss
W Yang, X Zhao, R Chai, J Fan - Frontiers in neuroscience, 2023 - frontiersin.org
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly
people worldwide. It typically presents as progressive, irreversible, and usually affects the …
people worldwide. It typically presents as progressive, irreversible, and usually affects the …
Predicting neural deficits in sensorineural hearing loss from word recognition scores
KJ Grant, A Parthasarathy, V Vasilkov… - Scientific reports, 2022 - nature.com
The current gold standard of clinical hearing assessment includes a pure-tone audiogram
combined with a word recognition task. This retrospective study tests the hypothesis that …
combined with a word recognition task. This retrospective study tests the hypothesis that …
The stria vascularis in mice and humans is an early site of age-related cochlear degeneration, macrophage dysfunction, and inflammation
Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting
communication and quality of life for millions of older adults. Multiple pathophysiologic …
communication and quality of life for millions of older adults. Multiple pathophysiologic …
Predicting atrophy of the cochlear stria vascularis from the shape of the threshold audiogram
Several lines of evidence have suggested that steeply sloping audiometric losses are
caused by hair cell degeneration, while flat audiometric losses are caused by strial atrophy …
caused by hair cell degeneration, while flat audiometric losses are caused by strial atrophy …
Recent advances and future challenges in gene therapy for hearing loss
AE Amariutei, JY Jeng… - Royal Society Open …, 2023 - royalsocietypublishing.org
Hearing loss is the most common sensory deficit experienced by humans and represents
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …
Cochlear immune response in presbyacusis: a focus on dysregulation of macrophage activity
K Noble, LS Brown, P Elvis, H Lang - … of the Association for Research in …, 2022 - Springer
Age-related hearing loss, or presbyacusis, is a prominent chronic degenerative disorder that
affects many older people. Based on presbyacusis pathology, the degeneration occurs in …
affects many older people. Based on presbyacusis pathology, the degeneration occurs in …
Metabolic and Sensory Components of Age-Related Hearing Loss: Associations With Distortion-and Reflection-Based Otoacoustic Emissions
KI Vaden Jr, ST Neely, SE Harris… - Trends in …, 2023 - journals.sagepub.com
Age-related hearing loss is difficult to study in humans because multiple genetic and
environmental risk factors may contribute to pathology and cochlear function declines in …
environmental risk factors may contribute to pathology and cochlear function declines in …
A machine learning–based biological aging prediction and its associations with healthy lifestyles: the Dongfeng–Tongji cohort
C Wang, X Guan, Y Bai, Y Feng, W Wei… - Annals of the New …, 2022 - Wiley Online Library
This study aims to establish a biological age (BA) predictor and to investigate the roles of
lifestyles on biological aging. The 14,848 participants with the available information of …
lifestyles on biological aging. The 14,848 participants with the available information of …
Statins and hearing
DS Whitlon - Hearing research, 2022 - Elsevier
Statins are a class of drugs that are widely used for the treatment of hyperlipidemia and the
prevention of heart attack and stroke. These drugs inhibit the rate-limiting step in the …
prevention of heart attack and stroke. These drugs inhibit the rate-limiting step in the …