Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss

K Hough, CA Verschuur, C Cunningham, TA Newman - Glia, 2022 - Wiley Online Library
Macrophages are abundant in the cochlea; however, their role in hearing loss is not well
understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an …

Progress on mechanisms of age-related hearing loss

W Yang, X Zhao, R Chai, J Fan - Frontiers in neuroscience, 2023 - frontiersin.org
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly
people worldwide. It typically presents as progressive, irreversible, and usually affects the …

Predicting neural deficits in sensorineural hearing loss from word recognition scores

KJ Grant, A Parthasarathy, V Vasilkov… - Scientific reports, 2022 - nature.com
The current gold standard of clinical hearing assessment includes a pure-tone audiogram
combined with a word recognition task. This retrospective study tests the hypothesis that …

The stria vascularis in mice and humans is an early site of age-related cochlear degeneration, macrophage dysfunction, and inflammation

H Lang, KV Noble, JL Barth, JA Rumschlag… - Journal of …, 2023 - Soc Neuroscience
Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting
communication and quality of life for millions of older adults. Multiple pathophysiologic …

Predicting atrophy of the cochlear stria vascularis from the shape of the threshold audiogram

C Kaur, PZ Wu, JT O'Malley… - Journal of …, 2023 - Soc Neuroscience
Several lines of evidence have suggested that steeply sloping audiometric losses are
caused by hair cell degeneration, while flat audiometric losses are caused by strial atrophy …

Recent advances and future challenges in gene therapy for hearing loss

AE Amariutei, JY Jeng… - Royal Society Open …, 2023 - royalsocietypublishing.org
Hearing loss is the most common sensory deficit experienced by humans and represents
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …

Cochlear immune response in presbyacusis: a focus on dysregulation of macrophage activity

K Noble, LS Brown, P Elvis, H Lang - … of the Association for Research in …, 2022 - Springer
Age-related hearing loss, or presbyacusis, is a prominent chronic degenerative disorder that
affects many older people. Based on presbyacusis pathology, the degeneration occurs in …

Metabolic and Sensory Components of Age-Related Hearing Loss: Associations With Distortion-and Reflection-Based Otoacoustic Emissions

KI Vaden Jr, ST Neely, SE Harris… - Trends in …, 2023 - journals.sagepub.com
Age-related hearing loss is difficult to study in humans because multiple genetic and
environmental risk factors may contribute to pathology and cochlear function declines in …

A machine learning–based biological aging prediction and its associations with healthy lifestyles: the Dongfeng–Tongji cohort

C Wang, X Guan, Y Bai, Y Feng, W Wei… - Annals of the New …, 2022 - Wiley Online Library
This study aims to establish a biological age (BA) predictor and to investigate the roles of
lifestyles on biological aging. The 14,848 participants with the available information of …

Statins and hearing

DS Whitlon - Hearing research, 2022 - Elsevier
Statins are a class of drugs that are widely used for the treatment of hyperlipidemia and the
prevention of heart attack and stroke. These drugs inhibit the rate-limiting step in the …