Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement
J Domínguez, MJ Boeree, E Cambau… - The Lancet Infectious …, 2023 - thelancet.com
Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-
based methods being considered the gold standard for drug susceptibility testing, molecular …
based methods being considered the gold standard for drug susceptibility testing, molecular …
Drug-resistant tuberculosis: a persistent global health concern
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot
Multidrug-resistant tuberculosis (MDR-TB) is among the most frequent causes of death due
to antimicrobial resistance. Although only 3% of global TB cases are MDR, geographical …
to antimicrobial resistance. Although only 3% of global TB cases are MDR, geographical …
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …
largest single contributor to human mortality due to antimicrobial resistance. A few major …
Regulatory fine-tuning of mcr-1 increases bacterial fitness and stabilises antibiotic resistance in agricultural settings
Antibiotic resistance tends to carry fitness costs, making it difficult to understand how
resistance can be maintained in the absence of continual antibiotic exposure. Here we …
resistance can be maintained in the absence of continual antibiotic exposure. Here we …
Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay
Recent rises in incident tuberculosis (TB) cases in Paraguay and the increasing
concentration of TB within prisons highlight the urgency of targeting strategies to interrupt …
concentration of TB within prisons highlight the urgency of targeting strategies to interrupt …
Genotypic and spatial analysis of transmission dynamics of tuberculosis in Shanghai, China: a 10-year prospective population-based surveillance study
Background With improved tuberculosis (TB) control programs, the incidence of TB in China
declined dramatically over the past few decades, but recently the rate of decrease has …
declined dramatically over the past few decades, but recently the rate of decrease has …
The role of prisons in disseminating tuberculosis in Brazil: a genomic epidemiology study
KS Walter, PCP Dos Santos, TO Gonçalves… - The Lancet Regional …, 2022 - thelancet.com
Background Globally, prisons are high-incidence settings for tuberculosis. Yet the role of
prisons as reservoirs of M. tuberculosis, propagating epidemics through spillover to …
prisons as reservoirs of M. tuberculosis, propagating epidemics through spillover to …
Scaling up evidence-based approaches to tuberculosis screening in prisons
People deprived of liberty have among the highest rates of tuberculosis globally. The
incidence of tuberculosis is ten times greater than the incidence of tuberculosis in the …
incidence of tuberculosis is ten times greater than the incidence of tuberculosis in the …
Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic …
Background Experimental data show that drug-resistance-conferring mutations are often
associated with a decrease in the replicative fitness of bacteria in vitro, and that this fitness …
associated with a decrease in the replicative fitness of bacteria in vitro, and that this fitness …