Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-
based methods being considered the gold standard for drug susceptibility testing, molecular …

People deprived of liberty have among the highest rates of tuberculosis globally. The
incidence of tuberculosis is ten times greater than the incidence of tuberculosis in the …

Multidrug-resistant tuberculosis (MDR-TB) is among the most frequent causes of death due
to antimicrobial resistance. Although only 3% of global TB cases are MDR, geographical …

Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …

Antibiotic resistance tends to carry fitness costs, making it difficult to understand how
resistance can be maintained in the absence of continual antibiotic exposure. Here we …

Recent rises in incident tuberculosis (TB) cases in Paraguay and the increasing
concentration of TB within prisons highlight the urgency of targeting strategies to interrupt …

Background With improved tuberculosis (TB) control programs, the incidence of TB in China
declined dramatically over the past few decades, but recently the rate of decrease has …

Background Globally, prisons are high-incidence settings for tuberculosis. Yet the role of
prisons as reservoirs of M. tuberculosis, propagating epidemics through spillover to …

Background Experimental data show that drug-resistance-conferring mutations are often
associated with a decrease in the replicative fitness of bacteria in vitro, and that this fitness …

Several human-adapted Mycobacterium tuberculosis complex (Mtbc) lineages exhibit a
restricted geographical distribution globally. These lineages are hypothesized to transmit …