[HTML][HTML] The molecular and cellular origin of human prostate cancer
JR Packer, NJ Maitland - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …
epidemiology, there are no definitive aetiological clues linking development to frequency …
Evolution of vertebrate sex chromosomes and dosage compensation
JAM Graves - Nature Reviews Genetics, 2016 - nature.com
Differentiated sex chromosomes in mammals and other vertebrates evolved independently
but in strikingly similar ways. Vertebrates with differentiated sex chromosomes share the …
but in strikingly similar ways. Vertebrates with differentiated sex chromosomes share the …
[HTML][HTML] Random allelic expression in the adult human body
SN Kravitz, E Ferris, MI Love, A Thomas, AR Quinlan… - Cell reports, 2023 - cell.com
Genes are typically assumed to express both parental alleles similarly, yet cell lines show
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …
Dosage compensation of the sex chromosomes and autosomes
CM Disteche - Seminars in cell & developmental biology, 2016 - Elsevier
Males are XY and females are XX in most mammalian species. Other species such as birds
have a different sex chromosome make-up: ZZ in males and ZW in females. In both types of …
have a different sex chromosome make-up: ZZ in males and ZW in females. In both types of …
Evolution of epigenetic regulation in vertebrate genomes
Empirical models of sequence evolution have spurred progress in the field of evolutionary
genetics for decades. We are now realizing the importance and complexity of the eukaryotic …
genetics for decades. We are now realizing the importance and complexity of the eukaryotic …
Monoallelic gene expression in mammals
A Chess - Annual Review of Genetics, 2016 - annualreviews.org
Monoallelic expression not due to cis-regulatory sequence polymorphism poses an
intriguing problem in epigenetics because it requires the unequal treatment of two segments …
intriguing problem in epigenetics because it requires the unequal treatment of two segments …
Genes with monoallelic expression contribute disproportionately to genetic diversity in humans
An unexpectedly large number of human autosomal genes are subject to monoallelic
expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic …
expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic …
Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation
AV Gendrel, L Marion-Poll, K Katoh, E Heard - Seminars in cell & …, 2016 - Elsevier
Genes are generally expressed from their two alleles, except in some particular cases such
as random inactivation of one of the two X chromosomes in female mammals or imprinted …
as random inactivation of one of the two X chromosomes in female mammals or imprinted …
Cell-to-cell variation in gene expression and the aging process
There is tremendous variation in biological traits, and much of it is not accounted for by
variation in DNA sequence, including human diseases and lifespan. Emerging evidence …
variation in DNA sequence, including human diseases and lifespan. Emerging evidence …
[HTML][HTML] Introns control stochastic allele expression bias
B Sands, S Yun, AR Mendenhall - Nature Communications, 2021 - nature.com
Monoallelic expression (MAE) or extreme allele bias can account for incomplete penetrance,
missing heritability and non-Mendelian diseases. In cancer, MAE is associated with shorter …
missing heritability and non-Mendelian diseases. In cancer, MAE is associated with shorter …